All your Writing needs covered

Editorial: molecular mechanism of neuronal dysfunction in the diabetic brain

Calculate the price
your order:

275 words
Approximate price
$ 0.00

Editorial: molecular mechanism of neuronal dysfunction in the diabetic brain

The Editorial on the Research Topic

Need an academic paper without any mistakes or plagiarism?
Our writers will create one from scratch for $13.00 $11.05/page!
311 professionals
Try it now!

Molecular Mechanism of Neuronal Dysfunction in the Diabetic Brain

Insulin signaling plays a significant role in the brain synaptic function. Insulin resistance is associated with reductions in cerebral glucose metabolism even in prediabetic individuals ( 1 ). Cognitive dysfunction in chronic diabetes is being recognized as a complication that needs to be seriously addressed. Epidemiological studies have also identified diabetes as a risk factor for Alzheimer’s disease (AD) ( 2 , 3 ). The link between diabetes and AD is further supported by studies in animal models ( 3 ). Chronic hyperglycemia-induced accumulation of advanced glycation end products (AGEs) ( 4 ) and their receptor RAGE are among the mechanistic links between diabetes and AD ( 5 ). Soluble form of RAGE (sRAGE) acts as a decoy for RAGE and provides a counter-regulatory mechanism. Selvin et al. have reported that low levels of sRAGE increase the risk of diabetes and mortality ( 6 ). Decreased levels of sRAGE have been also observed in AD patients ( 7 ). In this special issue, six articles (three original reports and three reviews) highlight the interactions of these two aging-associated diseases from several angles.

2. Huang CC, Chung CM, Leu HB, Lin LY, Chiu CC, Hsu CY, et al. Diabetes mellitus and the risk of Alzheimer’s disease: a nationwide population-based study. PLoS One (2014)9 : e87095. doi: 10. 1371/journal. pone. 0087095

3. Ott A, Stolk R, Harskamp F. v., Pols H, Hoffman A, Breteler M. Diabetes mellitus and the risk of dementia. The Rotterdam study. Neurology (1999)53 : 1937–42. doi: 10. 1212/WNL. 53. 9. 1937

4. Goh SY, Cooper ME. Clinical review: the role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab (2008)93 : 1143–52. doi: 10. 1210/jc. 2007-1817

5. Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, et al. Advanced glycation endproducts and their receptor RAGE in Alzheimer’s disease. Neurobiol Aging (2011)32 : 763–77. doi: 10. 1016/j. neurobiolaging. 2009. 04. 016

3 hours!3 hours! In only 3 hours, we’ll deliver you a flawless & plagiarism-free paper on any subject Read More

6. Selvin E, Halushka MK, Rawlings AM, Hoogeveen RC, Ballantyne CM, Coresh J, et al. sRAGE and risk of diabetes, cardiovascular disease, and death. Diabetes (2013)62 : 2116–21. doi: 10. 2337/db12-1528

7. Liang F, Jia J, Wang S, Qin W, Liu G. Decreased plasma levels of soluble low density lipoprotein receptor-related protein-1 (sLRP) and the soluble form of the receptor for advanced glycation end products (sRAGE) in the clinical diagnosis of Alzheimer’s disease. J Clin Neurosci (2013)20 : 357–61. doi: 10. 1016/j. jocn. 2012. 06. 005

8. Vinik AI, Maser RE, Ziegler D. Autonomic imbalance: prophet of doom or scope for hope? Diabet Med (2011)28 : 643–51. doi: 10. 1111/j. 1464-5491. 2010. 03184. x

9. Velmurugan K, Bouchard R, Mahaffey G, Pugazhenthi S. Neuroprotective actions of glucagon-like peptide-1 in differentiated human neuroprogenitor cells. J Neurochem (2012)123 : 919–31. doi: 10. 1111/jnc. 12036

Basic features

  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support

On-demand options

  • Writer's samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading

Paper format

  • 275 words per page
  • 12pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, CHicago/Turabian, Havard)

Guaranteed originality

We guarantee 0% plagiarism! Our orders are custom made from scratch. Our team is dedicated to providing you academic papers with zero traces of plagiarism.

Affordable prices

We know how hard it is to pay the bills while being in college, which is why our rates are extremely affordable and within your budget. You will not find any other company that provides the same quality of work for such affordable prices.

Best experts

Our writer are the crème de la crème of the essay writing industry. They are highly qualified in their field of expertise and have extensive experience when it comes to research papers, term essays or any other academic assignment that you may be given!

Calculate the price of your order

You will get a personal manager and a discount.
We'll send you the first draft for approval by at
Total price:

Expert paper writers are just a few clicks away

Place an order in 3 easy steps. Takes less than 5 mins.

error: Content is protected !!
Open chat
Need Homework Help? Let's Chat
Need Help With Your Assignment? Lets Talk