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Primary Signs And Symptoms Of Cushing Syndrome

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Primary Signs And Symptoms Of Cushing Syndrome 1.Describe the primary signs and symptoms of Cushing syndrome. 2.What treatment and follow up options are there for her condition?   Answer: 1.Describe The Primary Signs And Symptoms Of Cushing Syndrome In the research, it has been found that Cushing syndrome generally happens when the body of an individual gets exposed to huge amount of hormone cortisol for a longer period of time (Lowe, Young Jr, Lyssikatos, Stratakis & Carney, 2017). Cushing syndrome is also known to be hypercortisolism and which mostly happens because of the utilization of oral corticosteroid pills. Cushing syndrome can be seen when the body of any person develops plenty of cortisol independently. The symptoms and signs of Cushing syndrome vary from person to person based on the levels of cortisol. The most common form of symptoms and signs of Cushing syndrome are changed in skin structure followed by progressive obesity.  The other kinds of signs related to Cushing syndrome are as follows: Accumulation of fatty tissues followed by weight gain in the face, between the two shoulders, around upper back and midsection of the body. Formation of acne. Irritability, hypertension, anxiety, and depression (Nieman, 2015). Loss of bones which further results in major fractures. Formation of purple or pink stretch marks over the skin of arms, thighs, abdomen, and breasts. Slow curing of infections, insect bites, and cuts. The most common symptoms of Cushing syndrome that are found in women are as follows: Absence or irregular menstrual cycle. The visibility of the facial and body hair gets increased and the hairs also become thicker (Nieman, Biller, Findling, Murad, Newell-Price, Savage & Tabarin, 2015).    The most common symptoms of Cushing syndrome that are found in men are as follows: It males there can be erectile dysfunction (Ceccato, Barbot, Zilio, Frigo, Albiger, Camozzi, & Scaroni, 2015). The decrease in the fertility. The decrease in libido.   2.Sara Hainesis had been suffering from Cushing syndrome and there are various kinds of treatments available that can be used for enhancing her health condition. The treatment-related to Cushing syndrome is specially prepared to reduce her increased level of cortisol within her body (Poidvin, Storey-London, Martinerie, Léger, Braun, Lahlou & Carel, 2016). The lists of treatments that can be given to her are as follows: Reducing the usage of corticosteroid: If the Cushing syndrome for Sara had occurred due to long-term use of corticosteroid pills, then her doctor can reduce the excessive dosage of that particular drug for controlling the disease. This method can also be used for managing her asthma. Surgery: If the Cushing syndrome results in forming a tumor on the body of Sara, then the doctor may instruct her for the surgical removal of that tumor (Daniel, Aylwin, Mustafa, Ball, Munir, Boelaert & Davis, 2015). Radiation therapy: It can be seen that if the surgeon is unable to remove the tumor on Sara, then the surgeon may recommend for radiation therapy with the help of a technique known to be stereotactic radiosurgery (Nieman, 2018). Medications: After the thorough research it has been found that medications can be utilized for controlling the cortisol production of Sara when the radiation therapy and surgery get failed. It has been found that medications can be utilized much before any kind of surgery on her if she feels sicker due to Cushing syndrome (Nieman, Biller, Findling, Murad, Newell-Price, Savage & Tabarin, 2015). Most of the doctors usually instruct to use drug therapy before doing any kind of surgery for improving the symptoms thereby minimizing the risks related to surgery. The types of medications that are recommended for Sara includes metopirone, lysodren, and nizoral.   References Ceccato, F., Barbot, M., Zilio, M., Frigo, A. C., Albiger, N., Camozzi, V., … & Scaroni, C. (2015). Screening tests for Cushing’s syndrome: urinary free cortisol role measured by LC-MS/MS. The Journal of Clinical Endocrinology & Metabolism, 100(10), 3856-3861. Daniel, E., Aylwin, S., Mustafa, O., Ball, S., Munir, A., Boelaert, K., … & Davis, J. (2015). The effectiveness of metyrapone in treating Cushing’s syndrome: a retrospective multicenter study in 195 patients. The Journal of Clinical Endocrinology & Metabolism, 100(11), 4146-4154. Lowe, K. M., Young Jr, W. F., Lyssikatos, C., Stratakis, C. A., & Carney, J. A. (2017). Cushing Syndrome in Carney Complex: Clinical, Pathological, and Molecular Genetic Findings in the 17 Affected Mayo Clinic Patients. The American journal of surgical pathology, 41(2), 171. Nieman, L. K. (2015). Cushing’s syndrome: update on signs, symptoms and biochemical screening. European journal of endocrinology, 173(4), M33-M38. Nieman, L. K. (2018). Recent Updates on the Diagnosis and Management of Cushing’s Syndrome. Endocrinology and Metabolism, 33(2), 139-146. Nieman, L. K., Biller, B. M., Findling, J. W., Murad, M. H., Newell-Price, J., Savage, M. O., & Tabarin, A. (2015). Treatment of Cushing’s syndrome: an endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 100(8), 2807-2831. Nieman, L. K., Biller, B. M., Findling, J. W., Murad, M. H., Newell-Price, J., Savage, M. O., & Tabarin, A. (2015). Treatment of Cushing’s syndrome: an endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 100(8), 2807-2831. Poidvin, A., Storey-London, C., Martinerie, L., Léger, J., Braun, K., Lahlou, N., & Carel, J. C. (2016). Successful medical management of severe neonatal Cushing syndrome with metyrapone, guided by mass spectrometry monitoring. Delta, 30, 40.

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